Search results for "DCI = delayed cerebral ischemia"

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Vasoactive peptide urotensin II in plasma is associated with cerebral vasospasm after aneurysmal subarachnoid hemorrhage and constitutes a potential …

2019

National audience; OBJECTIVECerebral vasospasm (VS) is a severe complication of aneurysmal subarachnoid hemorrhage (SAH). Urotensin II (UII) is a potent vasoactive peptide activating the urotensin (UT) receptor, potentially involved in brain vascular pathologies. The authors hypothesized that UII/UT system antagonism with the UT receptor antagonist/biased ligand urantide may be associated with post-SAH VS. The objectives of this study were 2-fold: 1) to leverage an experimental mouse model of SAH with VS in order to study the effect of urotensinergic system antagonism on neurological outcome, and 2) to investigate the association between plasma UII level and symptomatic VS after SAH in huma…

SAPS II = Simplified Acute Physiology Score IIMCA = middle cerebral arteryAUC = area under the curvesubarachnoid hemorrhage[SDV]Life Sciences [q-bio]ICU = intensive care unitUT = urotensin (receptor)vascular disordersintensive care unitUII = urotensin IIcardiovascular diseaseshumanmouseWFNS = World Federation of Neurosurgical SocietiesEVD = external ventricular drainageACA = anterior cerebral arteryurotensin IInervous system diseasesSAH = subarachnoid hemorrhageSE = standard errorROC = receiver operating characteristic[SDV] Life Sciences [q-bio]cerebral vasospasmVS = vasospasmDCI = delayed cerebral ischemiaCSF = cerebrospinal fluidIRB = institutional review boardmRS = modified Rankin ScaleIQR = interquartile range
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